SCHEMBL8932417

SCHEMBL8932417

O=C(SC1CNC(=S)NC1)c1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.35
CHRNB4 P30926 2/20 0.35
CHRNA3 P32297 2/20 0.35
CHRNA7 P36544 2/20 0.35
CHRNA4 P43681 2/20 0.35
ACE P12821 1/20 0.34
ALDH1A1 P00352 2/20 0.33
CES2 O00748 2/20 0.33
CES1 P23141 2/20 0.33
DAO P14920 1/20 0.33
TSHR P16473 1/20 0.33
NAPRT Q6XQN6 1/20 0.33
TOP2A P11388 1/20 0.33
SLC22A12 Q96S37 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
NPC1 O15118 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27838683 0.82 CHRNB2 (0.46) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL9203598 0.79 MTNR1A (0.36) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL8932390 0.75 ALDH1A1 (0.33) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
Trifluoroacetic Acid SCHEMBL21640637 0.74 CES1 (0.42) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL6397894 0.73 KMT2A (0.42) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL8759876 0.73 KMT2A (0.42) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL13042918 0.73 RAB9A (0.47) ACEALDH1A1CES2CES1DAO
SCHEMBL6057177 0.72 ALDH1A1 (0.50) ACEALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL8932630 0.71 CHRNB2 (0.32) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL11003511 0.69 CHRNB2 (0.37) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996026939-A1 CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-09-06 WO disclosed