Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7781426 | 0.88 | MAPT (0.46) | MAPTLMNASMN1; SMN2HTTKMT2A | |
| SCHEMBL29993506 | 0.85 | LHCGR (0.41) | LSSMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL4297139 | 0.85 | SMN1; SMN2 (0.49) | MAPTLMNASMN1; SMN2HTTKMT2A | |
| SCHEMBL2463727 | 0.84 | LMNA (0.59) | LSSMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL12020270 | 0.80 | LTA4H (0.52) | LMNAHTTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11167581 | 0.79 | RAB9A (0.49) | MAPTLMNASMN1; SMN2HTTKMT2A | |
| SCHEMBL6788776 | 0.79 | ALDH1A1 (0.49) | ALDH1A1 | |
| SCHEMBL11659788 | 0.78 | MAPT (0.50) | MAPTLMNASMN1; SMN2HTTKMT2A | |
| SCHEMBL30738654 | 0.77 | RAB9A (0.73) | LMNASMN1; SMN2KMT2AALDH1A1PKM | |
| SCHEMBL5155573 | 0.76 | RAB9A (0.43) | MAPTLMNASMN1; SMN2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996025936-A1 | 2,6-DIARYL PYRIDAZINONES WITH IMMUNOSUPPRESSANT ACTIVITY | MERCK & CO., INC. (US) | 1996-08-29 | — | — | WO | disclosed |