SCHEMBL8934533

SCHEMBL8934533

Cc1ccn2c(C)c(CCc3ccc(NC4=NCCS4)cc3)nc2c1

nearest known ligand 0.50

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
NPY1R P25929 13/20 0.50
AOC3 Q16853 1/20 0.45
POLB P06746 1/20 0.40
CYP1A2 P05177 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
HPGD P15428 1/20 0.37
ALDH1A1 P00352 1/20 0.37
GAA P10253 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8934504 0.90 NPY1R (0.48) NPY1RAOC3POLBSMN1; SMN2HPGD
Fumaric Acid SCHEMBL8934542 0.82 MAPT (0.39) NPY1RAOC3POLBSMN1; SMN2HPGD
Fumaric Acid SCHEMBL8934540 0.82 MAPT (0.39) NPY1RAOC3POLBSMN1; SMN2HPGD
SCHEMBL8934581 0.82 TP53 (0.36) NPY1RPOLBSMN1; SMN2ALDH1A1GAA
SCHEMBL8934518 0.80 NPY1R (0.50) NPY1RAOC3POLBSMN1; SMN2HPGD
SCHEMBL8934592 0.80 MAPT (0.37) POLBSMN1; SMN2HPGDALDH1A1GAA
SCHEMBL8934556 0.80 ADRA2A (0.48) AOC3
Hydrochloric Acid SCHEMBL8934527 0.79 CRHBP (0.40) POLBSMN1; SMN2ALDH1A1GAA
SCHEMBL8934612 0.74 TP53 (0.36) AOC3POLBSMN1; SMN2ALDH1A1GAA
SCHEMBL8934510 0.74 NPC1 (0.41) POLBSMN1; SMN2ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996030350-A1 AMIDINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-10-03 WO disclosed