Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 16/20 | 0.56 |
| ▸ | FNTB | P49356 | 16/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.51 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8517000 | 0.80 | FNTA (0.66) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8369448 | 0.80 | FNTA (0.68) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8517002 | 0.80 | FNTA (0.66) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8369449 | 0.80 | FNTA (0.68) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8936963 | 0.77 | L3MBTL1 (0.53) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8936960 | 0.77 | L3MBTL1 (0.53) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8936962 | 0.76 | FNTA (0.83) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8936964 | 0.76 | FNTA (0.83) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL1830055 | 0.76 | LOXL2 (0.54) | — | |
| SCHEMBL8937032 | 0.76 | FNTA (0.59) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578629-A | ANTICARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| WO-1996030015-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |
| US-5534537-A | Prodrugs of inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1996-07-09 | — | — | US | disclosed |