Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.50 |
| ▸ | VNN1 | O95497 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937532 | 1.00 | P4HB (0.50) | P4HBVNN1GSK3BPDE4APDE4B | |
| SCHEMBL8937528 | 1.00 | P4HB (0.50) | P4HBVNN1GSK3BPDE4APDE4B | |
| SCHEMBL4394754 | 0.82 | CES2 (0.65) | CES2CES1ALDH1A1CYP3A4 | |
| SCHEMBL4394758 | 0.82 | CES2 (0.65) | CES2CES1ALDH1A1CYP3A4 | |
| SCHEMBL4390225 | 0.82 | CES2 (0.65) | CES2CES1ALDH1A1CYP3A4 | |
| SCHEMBL7780410 | 0.81 | VNN1 (0.63) | P4HBVNN1GSK3BMAPK14ALDH1A1 | |
| SCHEMBL9396296 | 0.80 | CES2 (0.62) | PDE4APDE4BPDE4CPDE4DCES2 | |
| SCHEMBL8937491 | 0.80 | ALDH1A1 (0.60) | CES2CES1ALDH1A1 | |
| SCHEMBL8937271 | 0.80 | CES2 (0.47) | CES2CES1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8937278 | 0.80 | CES2 (0.47) | CES2CES1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |