Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.41 |
| ▸ | CCR3 | P51677 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.38 |
| ▸ | SCN1A | P35498 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935610 | 0.95 | HRH1 (0.43) | HRH1CCR3KCNH2MAOAMAOB | |
| SCHEMBL8935590 | 0.89 | MAOB (0.49) | HRH1CCR3KCNH2MAOAMAOB | |
| SCHEMBL8938841 | 0.88 | OPRM1 (0.43) | HRH1CCR3KCNH2MAOAMAOB | |
| SCHEMBL8935571 | 0.88 | MAOA (0.52) | HRH1CCR3KCNH2MAOAMAOB | |
| SCHEMBL8935605 | 0.86 | MAOA (0.48) | MAOAMAOBSCN8ASCN1ADRD2 | |
| SCHEMBL8938789 | 0.86 | ROCK1 (0.51) | HRH1CCR3KCNH2MEN1KMT2A | |
| SCHEMBL8939144 | 0.85 | ROCK1 (0.52) | HRH1CCR3MEN1KMT2AMAOA | |
| SCHEMBL8939080 | 0.83 | HRH1 (0.39) | HRH1CCR3KCNH2MEN1KMT2A | |
| SCHEMBL8938967 | 0.83 | HRH1 (0.44) | HRH1CCR3KCNH2MEN1KMT2A | |
| SCHEMBL8935595 | 0.82 | HRH1 (0.46) | HRH1CCR3KCNH2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |
| US-20090093518-A1 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093518-A1 | Piperidinyl-substituted isoquinolone derivatives | MYLK2, MYLK, RHOT2 | HRH1 2936/4885CCR3 3890/4885KCNH2 2400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.