Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.41 |
| ▸ | CCR3 | P51677 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8935590 | 0.93 | MAOB (0.49) | OPRM1HRH1CCR3MAOAMAOB | |
| SCHEMBL8935605 | 0.92 | MAOA (0.48) | MAOAMAOBACHESCN1ASCN8A | |
| SCHEMBL8935610 | 0.89 | HRH1 (0.43) | HRH1CCR3MAOAMAOBSCN1A | |
| SCHEMBL8938834 | 0.88 | HRH1 (0.41) | HRH1CCR3MAOAMAOBSCN1A | |
| SCHEMBL8938824 | 0.87 | OPRM1 (0.48) | OPRM1HRH1CCR3SCN1ASCN8A | |
| SCHEMBL8935571 | 0.87 | MAOA (0.52) | OPRM1HRH1CCR3MAOAMAOB | |
| SCHEMBL8935224 | 0.85 | ROCK1 (0.55) | HRH1CCR3MAOAMAOBBCHE | |
| SCHEMBL8935441 | 0.85 | HRH1 (0.41) | HRH1CCR3MAOAMAOBKCNH2 | |
| SCHEMBL8937943 | 0.84 | ROCK1 (0.56) | OPRM1MAOAMAOBBCHEACHE | |
| SCHEMBL8935587 | 0.84 | OPRM1 (0.47) | OPRM1HRH1CCR3BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |
| US-20090093518-A1 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093518-A1 | Piperidinyl-substituted isoquinolone derivatives | MYLK2, MYLK, RHOT2 | OPRM1 3345/4885HRH1 2936/4885CCR3 3890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.