Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 13/20 | 0.79 |
| ▸ | PDK2 | Q15119 | 13/20 | 0.79 |
| ▸ | PDK3 | Q15120 | 13/20 | 0.79 |
| ▸ | PDK4 | Q16654 | 13/20 | 0.79 |
| ▸ | ABCC9 | O60706 | 9/20 | 0.66 |
| ▸ | ABCC8 | Q09428 | 9/20 | 0.66 |
| ▸ | KCNJ11 | Q14654 | 9/20 | 0.66 |
| ▸ | KCNJ8 | Q15842 | 9/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6357109 | 0.89 | PDK1 (0.72) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL8939407 | 0.86 | PDK1 (0.61) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL6350981 | 0.84 | PDK1 (0.69) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL6358595 | 0.84 | PDK1 (1.00) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL29118239 | 0.83 | ALDH1A1 (0.58) | PDK1PDK2PDK3PDK4ABCC9 | |
| Zd-6169 SCHEMBL2123811 | 0.79 | ABCC9 (1.00) | PDK1PDK2PDK3PDK4ABCC9 | |
| Zd-6169 SCHEMBL4261046 | 0.79 | ABCC9 (1.00) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL4608131 | 0.79 | ABCC9 (1.00) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL4608961 | 0.79 | ABCC9 (1.00) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL4609784 | 0.79 | ABCC9 (1.00) | PDK1PDK2PDK3PDK4ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5567735-A | CELL POTASSIUM CHANNEL MODULATOR FOR TREATING ASTHMA | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-10-22 | — | — | US | disclosed |
| US-5565477-A | TREATMENT OF URINARY INCONTINENCE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-10-15 | — | — | US | disclosed |
| US-5565465-A | TREATMENT OF URINARY INCONTINENCE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-10-15 | — | — | US | disclosed |
| EP-0524781-B1 | Therapeutic amides | ZENECA LTD (GB) | 1996-03-27 | — | — | EP | disclosed |
| US-5474999-A | Useful in treatment of urinary incontinence | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-12-12 | — | — | US | disclosed |
| US-5382598-A | Therapeutic amides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-01-17 | — | — | US | disclosed |
| US-5272163-A | Therapeutic amides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-21 | — | — | US | disclosed |
| EP-0524781-A1 | Therapeutic amides | ZENECA LIMITED (GB) | 1993-01-27 | — | — | EP | disclosed |