Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 2/20 | 0.51 |
| ▸ | BACE1 | P56817 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939645 | 0.86 | KMT2A (0.55) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8939654 | 0.81 | ALDH1A1 (0.51) | KMT2AMEN1CYP3A4RECQLHTT | |
| SCHEMBL8939701 | 0.81 | ALDH1A1 (0.51) | KMT2AMEN1CYP3A4RECQLHTT | |
| SCHEMBL8939610 | 0.81 | ALDH1A1 (0.51) | KMT2AMEN1CYP3A4RECQLHTT | |
| SCHEMBL9126589 | 0.78 | SIGMAR1 (0.62) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9123556 | 0.78 | ACHE (0.67) | KMT2AMEN1ACHEBACE1SIGMAR1 | |
| SCHEMBL3961060 | 0.76 | HTT (0.64) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6965515 | 0.74 | HTT (0.85) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6749008 | 0.73 | HTT (0.65) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL3958348 | 0.73 | KMT2A (0.65) | KMT2AMEN1CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626369-B1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1996-09-18 | — | — | EP | disclosed |
| US-5523464-A | BONE DISORDERS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1996-06-04 | — | — | US | disclosed |
| EP-0626369-A1 | BENZENESULFONAMIDE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-11-30 | — | — | EP | disclosed |