Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL860875 | 0.82 | GHSR (0.40) | KCNH2ALOX15MEN1KMT2A | |
| SCHEMBL5110676 | 0.82 | HPGD (0.39) | L3MBTL1NPC1RAB9A | |
| SCHEMBL11445102 | 0.81 | GHSR (0.42) | KCNH2ALOX15MEN1KMT2A | |
| SCHEMBL1775664 | 0.81 | GHSR (0.42) | KCNH2ALOX15MEN1KMT2A | |
| SCHEMBL9485874 | 0.80 | GHSR (0.35) | ALOX15NPC1RAB9A | |
| SCHEMBL8939760 | 0.76 | MAOA (0.41) | L3MBTL1MAOASIGMAR1MAOBIGF1R | |
| SCHEMBL11973370 | 0.74 | ACHE (0.42) | L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL11396987 | 0.73 | TP53 (0.46) | L3MBTL1MAOASIGMAR1MAOBIGF1R | |
| SCHEMBL6294089 | 0.72 | MAOA (0.48) | L3MBTL1MAOASIGMAR1MAOB | |
| SCHEMBL4468701 | 0.72 | ALDH1A1 (0.34) | ALOX15MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |