Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7014345 | 0.80 | CALM1 (0.41) | ALOX15ALDH1A1HPGDALOX12CASP1 | |
| SCHEMBL6294089 | 0.76 | MAOA (0.48) | MAOAMAOBSIGMAR1L3MBTL1MAPT | |
| SCHEMBL8939710 | 0.76 | L3MBTL1 (0.39) | MAOAMAOBALOX15IGF1RSIGMAR1 | |
| SCHEMBL3028982 | 0.74 | SIGMAR1 (0.48) | MAOAMAOBSIGMAR1L3MBTL1MAPT | |
| SCHEMBL18917615 | 0.74 | SIGMAR1 (0.48) | MAOAMAOBSIGMAR1L3MBTL1MAPT | |
| SCHEMBL11553069 | 0.74 | SIGMAR1 (0.48) | MAOAMAOBSIGMAR1L3MBTL1MAPT | |
| SCHEMBL3021800 | 0.72 | SIGMAR1 (0.38) | MAOAMAOBSIGMAR1MAPTRXFP1 | |
| SCHEMBL8924194 | 0.72 | SIGMAR1 (0.40) | MAOASIGMAR1 | |
| SCHEMBL9125878 | 0.72 | — | — | |
| SCHEMBL3030818 | 0.72 | HTR2A (0.47) | MAOAMAOBSIGMAR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |