Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 2/20 | 0.48 |
| ▸ | HTR3A | P46098 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8940024 | 0.85 | HTR3A (0.52) | HTR4HTR3AMEN1KMT2AHTR3E | |
| SCHEMBL8939959 | 0.81 | PARP1 (0.53) | HTR3AMEN1KMT2AHTR3EHTR3B | |
| SCHEMBL8940123 | 0.80 | HTR4 (0.48) | HTR4HTR3AMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9204228 | 0.80 | PARP1 (0.52) | HTR3AMEN1KMT2AHTR3EHTR3B | |
| SCHEMBL7126040 | 0.74 | PARP1 (0.49) | — | |
| Hydrochloric Acid SCHEMBL7281701 | 0.70 | HTR3A (0.49) | HTR4HTR3AMEN1KMT2A | |
| SCHEMBL8940010 | 0.67 | L3MBTL1 (0.61) | MEN1KMT2A | |
| SCHEMBL7276342 | 0.67 | HTR3A (0.50) | HTR4HTR3AMEN1KMT2AHTR3E | |
| SCHEMBL19456170 | 0.66 | BRD4 (0.55) | — | |
| SCHEMBL8940139 | 0.66 | HTR4 (0.55) | HTR4HTR3AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563148-A | BICYCLIC ESTERS OR AMIDES; USED IN TREATING MIGRAINE, EMESIS, GASTROINTESTINAL DISORDERS, SCHIZOPHRENIA OR ANXIETY IN MAMMALS | ELI LILLY AND COMPANY (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0307172-B1 | Improvements in or relating to specific 5-HT3 antagonists | LILLY CO ELI (US) | 1995-10-11 | — | — | EP | disclosed |
| US-5442078-A | Intermediates for specific 5-HT3 antagonists | ELI LILLY AND COMPANY (US) | 1995-08-15 | — | — | US | disclosed |
| US-5364863-A | Treatment of migraine, emesis, schizophrenia, anxiety, gastrointestinal disorders | ELI LILLY AND COMPANY (US) | 1994-11-15 | — | — | US | disclosed |
| US-4997956-A | Analgesics | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| US-4921982-A | 5-halo-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acids useful as intermediates for 5-HT3 antagonists | ELI LILLY AND COMPANY (US) | 1990-05-01 | — | — | US | disclosed |