Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9786144 | 0.92 | KMT2A (0.47) | ALDH1A1TSHRMAPK1MAPTTHRB | |
| SCHEMBL8942151 | 0.88 | STAT3 (0.45) | ALDH1A1TSHRMAPK1MAPTTHRB | |
| SCHEMBL9775896 | 0.86 | ALDH1A1 (0.49) | ALDH1A1TSHRMAPK1MAPTTHRB | |
| SCHEMBL8941946 | 0.86 | ALDH1A1 (0.55) | ALDH1A1TSHRMAPK1MAPTTHRB | |
| SCHEMBL9775904 | 0.85 | LMNA (0.56) | ALDH1A1TSHRMAPK1MAPTTHRB | |
| SCHEMBL9775866 | 0.85 | STAT3 (0.43) | ALDH1A1TSHRMAPK1MAPTTHRB | |
| SCHEMBL7230077 | 0.83 | ADRB2 (0.50) | ALDH1A1TSHRKMT2ALMNAKDM4E | |
| SCHEMBL9775892 | 0.82 | LMNA (0.53) | ALDH1A1TSHRMAPK1MAPTTHRB | |
| SCHEMBL3977245 | 0.82 | ALDH1A1 (0.53) | ALDH1A1TSHRMAPK1MAPTTHRB | |
| SCHEMBL9775959 | 0.82 | ALDH1A1 (0.52) | ALDH1A1TSHRMAPK1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |