Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 3/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 4/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536515 | 0.88 | LMNA (0.32) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775901 | 0.86 | TOP2A (0.38) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL8942074 | 0.85 | KMT2A (0.46) | LMNAKMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL9775920 | 0.84 | ALDH1A1 (0.52) | LMNAKMT2AMEN1KDM4EHSD17B10 | |
| SCHEMBL9775973 | 0.84 | ALDH1A1 (0.52) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL6605949 | 0.84 | LMNA (0.41) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL8942372 | 0.83 | TOP2A (0.33) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL8941977 | 0.83 | KMT2A (0.38) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL8942065 | 0.82 | TOP1 (0.41) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL8942028 | 0.81 | LMNA (0.59) | LMNACYP2C9ATP6V1B2TBXA2REDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379413-B1 | 1,8-Benzonaphthyridine derivatives, their production and compositions containing them | BELLON LABOR SA ROGER (FR) | 1993-12-22 | — | — | EP | claimed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | claimed |
| US-5556861-A | 1,8 benzonaphthyridine derivatives and antimicrobial compositions | LABORATOIRE ROGER BELLON (FR) | 1996-09-17 | — | — | US | disclosed |
| US-5053509-A | Microbiocides; AIDS | LABORATOIRE ROGER BELLON (FR) | 1991-10-01 | — | — | US | disclosed |
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |