Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8942417 | 0.83 | LMNA (0.39) | TOP2ATOP2BLMNACYP2C9ATP6V1B2 | |
| SCHEMBL8136324 | 0.75 | ALDH1A1 (0.44) | TOP2ATOP2BLMNACYP2C9ALDH1A1 | |
| SCHEMBL9259220 | 0.72 | MAP2K1 (0.37) | ALDH1A1KDM4EHPGD | |
| SCHEMBL9775901 | 0.71 | TOP2A (0.38) | TOP2ATOP2BLMNACYP2C9ATP6V1B2 | |
| SCHEMBL9536515 | 0.71 | LMNA (0.32) | TOP2ATOP2BLMNACYP2C9ATP6V1B2 | |
| SCHEMBL9775973 | 0.71 | ALDH1A1 (0.52) | TOP2ATOP2BLMNACYP2C9ATP6V1B2 | |
| SCHEMBL9775920 | 0.69 | ALDH1A1 (0.52) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8942074 | 0.69 | KMT2A (0.46) | LMNAALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL6605949 | 0.68 | LMNA (0.41) | TOP2ATOP2BLMNACYP2C9ATP6V1B2 | |
| SCHEMBL6213315 | 0.68 | ALDH1A1 (0.41) | TOP2ATOP2BLMNACYP2C9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556861-A | 1,8 benzonaphthyridine derivatives and antimicrobial compositions | LABORATOIRE ROGER BELLON (FR) | 1996-09-17 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |