Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 5/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9775958 | 0.87 | STAT3 (0.44) | LMNAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL8942417 | 0.86 | LMNA (0.39) | TOP2ATOP2BLMNACYP2C9ATP6V1B2 | |
| SCHEMBL9536515 | 0.74 | LMNA (0.32) | TOP2ATOP2BLMNACYP2C9ATP6V1B2 | |
| SCHEMBL8942074 | 0.74 | KMT2A (0.46) | LMNAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9775920 | 0.74 | ALDH1A1 (0.52) | LMNAKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL9775973 | 0.73 | ALDH1A1 (0.52) | TOP2ATOP2BLMNACYP2C9ATP6V1B2 | |
| SCHEMBL8941977 | 0.73 | KMT2A (0.38) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL8942065 | 0.72 | TOP1 (0.41) | TOP2ATOP2BLMNACYP2C9ATP6V1B2 | |
| SCHEMBL8942372 | 0.71 | TOP2A (0.33) | TOP2ATOP2BLMNACYP2C9ATP6V1B2 | |
| SCHEMBL8136324 | 0.71 | ALDH1A1 (0.44) | TOP2ATOP2BLMNACYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |