SCHEMBL8943663

SCHEMBL8943663

COc1ccc(Nc2ccc(OCCOc3cccc(N(c4ccccc4)c4ccccc4)c3)c(Nc3ccc(OC)cc3)c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.41
MEN1 O00255 4/20 0.41
NPC1 O15118 4/20 0.41
KMT2A Q03164 4/20 0.41
MAPT P10636 4/20 0.40
MAPK1 P28482 3/20 0.40
ALOX12 P18054 1/20 0.40
HSD17B10 Q99714 1/20 0.40
NPSR1 Q6W5P4 2/20 0.39
EGFR P00533 3/20 0.38
ERBB3 P21860 2/20 0.38
ALDH1A1 P00352 2/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
PPARG P37231 1/20 0.38
SRC P12931 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8944076 0.89 MAPT (0.43) RAB9AMEN1NPC1KMT2AMAPT
SCHEMBL8943630 0.83 DRD2 (0.39) RAB9ANPC1KMT2AMAPTMAPK1
SCHEMBL8943885 0.83 RAB9A (0.39) RAB9AMEN1NPC1KMT2AMAPT
SCHEMBL8943581 0.82 MAPT (0.55) RAB9AMEN1NPC1KMT2AMAPT
SCHEMBL8944352 0.80 EGFR (0.48) RAB9AMEN1NPC1KMT2AMAPT
SCHEMBL8944031 0.79 MAPT (0.45) RAB9AMEN1NPC1KMT2AMAPT
SCHEMBL8943901 0.78 EGFR (0.54) RAB9AMEN1NPC1KMT2AMAPT
SCHEMBL8944010 0.78 MAPT (0.53) RAB9AMEN1NPC1KMT2AMAPT
SCHEMBL8944086 0.77 MAPT (0.49) RAB9AMEN1NPC1KMT2AMAPT
SCHEMBL8944395 0.77 MAPT (0.52) RAB9AMEN1NPC1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5480765-A PRESSURE AND HEAT SENSITIVE PAPER, IMPROVED PHOTOSTABILITY BY ADDITION OF TRIARYLAMINE COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1996-01-02 US disclosed