Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | CCR8 | P51685 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17099988 | 0.81 | LMNA (0.51) | LMNACYP3A4MAPTKDM4EATM | |
| SCHEMBL1586524 | 0.79 | LMNA (0.50) | LMNACYP3A4MAPTKDM4EATM | |
| SCHEMBL8944459 | 0.75 | LMNA (0.61) | LMNACYP3A4MAPTKDM4ECCR1 | |
| SCHEMBL7720171 | 0.75 | ATM (0.49) | LMNACYP3A4MAPTKDM4EATM | |
| SCHEMBL8358335 | 0.75 | LMNA (0.42) | LMNACYP3A4MAPTKDM4EATM | |
| Phosphoric Acid SCHEMBL29226180 | 0.74 | ATM (0.48) | LMNACYP3A4MAPTKDM4EATM | |
| SCHEMBL7715992 | 0.74 | ATM (0.48) | LMNACYP3A4MAPTKDM4EATM | |
| SCHEMBL10923942 | 0.73 | LMNA (0.53) | LMNACYP3A4MAPTKDM4ECCR1 | |
| SCHEMBL462223 | 0.72 | LMNA (0.56) | LMNACYP3A4MAPTKDM4ECCR1 | |
| SCHEMBL10342775 | 0.71 | CCR1 (0.61) | LMNACYP3A4MAPTKDM4ECCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545639-A | USING 2,9-BIS(HALOMETHYL)-1,10-PHENANTHROLINE | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1996-08-13 | — | — | US | disclosed |
| US-4598073-A | Certain polycyclo-palladium-bipyridine complexes having anti-tumor activity | RESEARCH CORPORATION (US) | 1986-07-01 | — | — | US | disclosed |