Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944813 | 0.93 | NISCH (0.47) | NISCHSIGMAR1 | |
| SCHEMBL8944702 | 0.82 | NISCH (0.42) | NISCHSIGMAR1 | |
| SCHEMBL8944755 | 0.79 | LMNA (0.40) | NISCH | |
| SCHEMBL8944664 | 0.79 | NISCH (0.48) | NISCHSIGMAR1 | |
| SCHEMBL8944697 | 0.78 | HTR1B (0.49) | NISCHSIGMAR1 | |
| SCHEMBL8944498 | 0.78 | TAAR1 (0.42) | NISCH | |
| SCHEMBL8944628 | 0.78 | ADRA2A (0.41) | NISCH | |
| SCHEMBL8944681 | 0.77 | MAPK1 (0.43) | NISCHMAPK1 | |
| SCHEMBL8944556 | 0.75 | GAA (0.45) | MAPK1 | |
| SCHEMBL8944902 | 0.75 | CYP2A13 (0.39) | NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |