Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944813 | 0.84 | NISCH (0.47) | NISCHSIGMAR1 | |
| SCHEMBL8944702 | 0.79 | NISCH (0.42) | NISCHSIGMAR1 | |
| SCHEMBL8944556 | 0.79 | GAA (0.45) | ALDH1A1KDM4EGAAKMT2APOLB | |
| SCHEMBL8944530 | 0.78 | ALDH1A1 (0.46) | ALDH1A1KDM4ENISCHGAAKMT2A | |
| SCHEMBL8944625 | 0.78 | NISCH (0.41) | NISCHSIGMAR1 | |
| SCHEMBL8944498 | 0.77 | TAAR1 (0.42) | NISCH | |
| SCHEMBL8944628 | 0.75 | ADRA2A (0.41) | ALDH1A1NISCHKMT2AMEN1 | |
| SCHEMBL8944902 | 0.74 | CYP2A13 (0.39) | ALDH1A1KDM4ENISCHPOLB | |
| SCHEMBL8944755 | 0.74 | LMNA (0.40) | NISCHKMT2A | |
| SCHEMBL8944681 | 0.74 | MAPK1 (0.43) | ALDH1A1KDM4ENISCHRORCKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |