Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Isophthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | UNG | P13051 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isophthalic Acid SCHEMBL5558793 | 0.91 | CA12 (0.50) | RXRARXRBUNGCA12CA1 | |
| Isophthalic Acid SCHEMBL3298198 | 0.91 | CA12 (0.50) | RXRARXRBUNGCA12CA1 | |
| Isophthalic Acid SCHEMBL3475846 | 0.91 | CA12 (0.50) | RXRARXRBUNGCA12CA1 | |
| Isophthalic Acid SCHEMBL8373778 | 0.88 | RXRA (0.47) | RXRARXRBUNGCA12CA1 | |
| Terephthalic Acid SCHEMBL6690767 | 0.88 | RXRA (0.47) | RXRARXRBCA12CA1CA2 | |
| Isophthalic Acid SCHEMBL10773395 | 0.84 | UNG (0.50) | UNGCA12CA1CA2CA6 | |
| Isophthalic Acid SCHEMBL9138888 | 0.84 | CA12 (0.58) | UNGCA12CA1CA2CA6 | |
| Isophthalic Acid SCHEMBL9138897 | 0.84 | CA12 (0.58) | UNGCA12CA1CA2CA6 | |
| Isophthalic Acid SCHEMBL11237361 | 0.84 | CA12 (0.58) | UNGCA12CA1CA2CA6 | |
| Isophthalic Acid SCHEMBL28394812 | 0.83 | RXRA (0.44) | RXRARXRBUNGCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545679-A | CURRENT LIMITERS, RESETTABLE FUSES | EATON CORPORATION (US) | 1996-08-13 | — | — | US | claimed |
| US-5545679-A | CURRENT LIMITERS, RESETTABLE FUSES | EATON CORPORATION (US) | 1996-08-13 | — | — | US | disclosed |
| US-5545679-A | CURRENT LIMITERS, RESETTABLE FUSES | EATON CORPORATION (US) | 1996-08-13 | — | — | US | disclosed |