Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944513 | 0.83 | SIGMAR1 (0.44) | CXCR4ALDH1A1HTTSIGMAR1KDM4E | |
| SCHEMBL8944554 | 0.83 | SIGMAR1 (0.44) | CXCR4ALDH1A1HTTSIGMAR1ROCK2 | |
| SCHEMBL8944769 | 0.80 | ALDH1A1 (0.47) | CXCR4ALDH1A1HTTSIGMAR1KDM4E | |
| SCHEMBL8944703 | 0.80 | SIGMAR1 (0.41) | CXCR4ALDH1A1HTTSIGMAR1KDM4E | |
| SCHEMBL8944864 | 0.79 | L3MBTL1 (0.42) | ALDH1A1HTTSIGMAR1MAPK1KDM4E | |
| SCHEMBL8944610 | 0.76 | KMT2A (0.39) | ALDH1A1HTTSIGMAR1KDM4EKMT2A | |
| SCHEMBL8944696 | 0.74 | NISCH (0.41) | HTTSIGMAR1KDM4EKMT2A | |
| SCHEMBL8944755 | 0.71 | LMNA (0.40) | KMT2A | |
| SCHEMBL8944819 | 0.71 | LMNA (0.38) | HTTKDM4EKMT2A | |
| SCHEMBL8944673 | 0.70 | LMNA (0.41) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |