Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1740752 | 0.86 | MEN1 (0.53) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL8944641 | 0.81 | ALDH1A1 (0.67) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL8944843 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| Trifluoroacetic Acid SCHEMBL6706496 | 0.80 | ALDH1A1 (0.51) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL8944884 | 0.78 | ALDH1A1 (0.57) | ALDH1A1KDM4ETSHRMAPK1RECQL | |
| SCHEMBL8948803 | 0.75 | CYP2C19 (0.48) | ALDH1A1TSHRMEN1KMT2ACYP2C19 | |
| SCHEMBL8944631 | 0.74 | ALDH1A1 (0.67) | ALDH1A1KDM4ETSHRMAPK1MEN1 | |
| SCHEMBL8245271 | 0.73 | MAPT (0.36) | ALDH1A1KDM4EGAAMAPTLMNA | |
| Piperazine SCHEMBL28073195 | 0.73 | MAPT (0.36) | ALDH1A1KDM4EKMT2AMAPTLMNA | |
| SCHEMBL6793000 | 0.73 | FKBP1A (0.46) | ALDH1A1MAPTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |