Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944641 | 0.88 | ALDH1A1 (0.67) | ALDH1A1KDM4ESMN1; SMN2MAPK1NPSR1 | |
| SCHEMBL9581725 | 0.85 | L3MBTL1 (0.55) | ALDH1A1KDM4EATML3MBTL1 | |
| SCHEMBL8944884 | 0.83 | ALDH1A1 (0.57) | ALDH1A1KDM4ESMN1; SMN2MAPK1NPSR1 | |
| SCHEMBL8944843 | 0.79 | ALDH1A1 (0.57) | ALDH1A1KDM4ESMN1; SMN2MAPK1NPSR1 | |
| SCHEMBL9204175 | 0.78 | ALDH1A1 (0.65) | ALDH1A1KDM4ESMN1; SMN2MAPK1NPSR1 | |
| SCHEMBL30426031 | 0.75 | ALDH1A1 (0.37) | ALDH1A1KDM4EKMT2ALMNAMAPT | |
| SCHEMBL8944874 | 0.74 | ALDH1A1 (0.54) | ALDH1A1KDM4ESMN1; SMN2MAPK1ATM | |
| SCHEMBL124103 | 0.73 | L3MBTL1 (0.55) | ALDH1A1KDM4ESMN1; SMN2ATMMEN1 | |
| SCHEMBL13464520 | 0.73 | MMP1 (0.50) | KMT2A | |
| SCHEMBL15490509 | 0.73 | AGTR2 (0.49) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638568-B1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1996-10-09 | — | — | EP | disclosed |
| US-5500426-A | ADMINISTERED TO IMPROVE GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| US-5492912-A | IMPROVES GLUCOSE TOLERANCE | ADIR ET COMPAGNIE (FR) | 1996-02-20 | — | — | US | disclosed |
| EP-0638568-A1 | Substituted piperazines, their process of preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-02-15 | — | — | EP | disclosed |