Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8945460 | 0.79 | KDM4E (0.40) | PRMT5KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL31353938 | 0.77 | PRMT5 (0.47) | PRMT5KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL30308911 | 0.76 | MMP2 (0.45) | PRMT5KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL3705881 | 0.76 | MMP2 (0.45) | PRMT5KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8945472 | 0.76 | KDM4E (0.46) | PRMT5KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8810477 | 0.73 | KDM4E (0.59) | KDM4ELMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11860802 | 0.73 | METAP2 (0.42) | PRMT5KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL8945215 | 0.73 | MMP2 (0.42) | PRMT5KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL31354076 | 0.72 | LMNA (0.41) | PRMT5KDM4ELMNAHTTSMN1; SMN2 | |
| SCHEMBL17049278 | 0.69 | RPS6KA5 (0.48) | KDM4ELMNAHTTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494887-A | Ring annulated 5-alkoxy-n-aryl[1,2,4]triazolo[1,5-C]-pyrimidine-2-sulfonamide herbicides | DOWELANCO (US) | 1996-02-27 | — | — | US | disclosed |