Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8946825 | 0.90 | DHODH (0.41) | MAPTMAPK1KMT2AALDH1A1 | |
| SCHEMBL8946540 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTMEN1MAPK1RECQL | |
| SCHEMBL8946710 | 0.82 | HTT (0.47) | SMN1; SMN2MAPTMEN1MAPK1KMT2A | |
| SCHEMBL8946714 | 0.78 | LMNA (0.43) | SMN1; SMN2KMT2A | |
| SCHEMBL8946885 | 0.78 | DHODH (0.49) | — | |
| SCHEMBL8946750 | 0.77 | L3MBTL1 (0.48) | SMN1; SMN2MAPTMEN1KMT2AHTT | |
| SCHEMBL8952284 | 0.77 | KDR (0.44) | SMN1; SMN2MAPTMEN1MAPK1RECQL | |
| SCHEMBL8823155 | 0.76 | NPC1 (0.49) | SMN1; SMN2MAPTNPC1RAB9AHTT | |
| SCHEMBL8946585 | 0.76 | KDR (0.40) | MEN1MAPK1KMT2A | |
| SCHEMBL9358286 | 0.75 | NPC1 (0.43) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5500424-A | ENZYME INHIBITORS | NIHON NOHYAKU CO., LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0638557-A1 | N-phenylpyri(mi)dine-N'-phenyl-urea derivatives, their preparation and their use as ACAT inhibitors | NIHON NOHYAKU CO., LTD. (JP) | 1995-02-15 | — | — | EP | disclosed |