Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | VEGFA | P15692 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947264 | 0.76 | P2RX7 (0.49) | P2RX7NPC1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL27953930 | 0.73 | P2RX7 (0.81) | P2RX7NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL17322839 | 0.72 | KDM4E (0.69) | KMT2AMAPTKDM4ESMN1; SMN2HPGD | |
| SCHEMBL22154181 | 0.70 | PTGS2 (0.43) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL14624106 | 0.70 | HDAC1 (0.50) | ALDH1A1LMNATSHRTP53CCNE1 | |
| SCHEMBL8269598 | 0.69 | BACE1 (0.52) | KMT2AMEN1KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8301498 | 0.69 | P2RX7 (0.45) | P2RX7NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL8269585 | 0.68 | BACE1 (0.55) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL27667439 | 0.68 | PTGS2 (0.48) | NPC1RAB9AKMT2AMAPTKDM4E | |
| SCHEMBL11036003 | 0.68 | TP53 (0.55) | NPC1RAB9AKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |