Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22154190 | 0.80 | ALDH1A1 (0.44) | PTGS2GAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL27667439 | 0.79 | PTGS2 (0.48) | PTGS2CYP1A2GAACYP2C19SMN1; SMN2 | |
| SCHEMBL20037188 | 0.71 | LMNA (0.66) | CYP1A2GAASMN1; SMN2RAB9AKDM4E | |
| SCHEMBL12126327 | 0.71 | — | — | |
| SCHEMBL8947126 | 0.70 | P2RX7 (0.47) | CYP1A2GAACYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL13631407 | 0.69 | MAPK1 (0.72) | CYP1A2GAACYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL20517131 | 0.69 | LMNA (0.45) | CYP1A2GAACYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL22154192 | 0.68 | MPO (0.37) | PTGS2CYP1A2CYP2C19SMN1; SMN2RAB9A | |
| SCHEMBL24666711 | 0.68 | PTGS2 (0.57) | PTGS2GAACYP2C19SMN1; SMN2KDM4E | |
| SCHEMBL8947317 | 0.68 | ALDH1A1 (0.57) | CYP1A2GAACYP2C19SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129518-A1 | TUBULYSINS AND PROTEIN-TUBULYSIN CONJUGATES | REGENERON PHARMACEUTICALS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |
| WO-2021262910-A2 | TUBULYSINS AND PROTEIN-TUBULYSIN CONJUGATES | REGENERON PHARMACEUTICALS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |
| WO-2020132658-A2 | TUBULYSINS AND PROTEIN-TUBULYSIN CONJUGATES | REGENERON PHARMACEUTICALS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |