Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.40 |
| ▸ | TUBB | P07437 | 2/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.40 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947118 | 0.88 | KDM4E (0.42) | ALDH1A1HPGDSMN1; SMN2KDM4ETP53 | |
| SCHEMBL8947235 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HPGDSMN1; SMN2LMNAKDM4E | |
| SCHEMBL8947174 | 0.83 | ALDH1A1 (0.50) | ALDH1A1HPGDSMN1; SMN2LMNAHSD11B1 | |
| SCHEMBL8947259 | 0.80 | ALDH1A1 (0.61) | ALDH1A1HPGDSMN1; SMN2LMNAHSD11B1 | |
| SCHEMBL5966725 | 0.78 | ALDH1A1 (0.68) | ALDH1A1HPGDSMN1; SMN2LMNAHSD11B1 | |
| SCHEMBL8947238 | 0.76 | RECQL (0.60) | ALDH1A1HPGDSMN1; SMN2LMNAKDM4E | |
| SCHEMBL8947331 | 0.76 | ALDH1A1 (0.84) | ALDH1A1HPGDLMNAHSD11B1KDM4C | |
| SCHEMBL17211730 | 0.74 | KDM4E (0.67) | ALDH1A1HPGDSMN1; SMN2LMNAKDM4E | |
| SCHEMBL5966727 | 0.74 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4EMAPTHSD11B1 | |
| SCHEMBL8947266 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HPGDSMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |