Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947235 | 0.88 | ALDH1A1 (0.59) | ALDH1A1HPGDLMNATP53HTT | |
| SCHEMBL8947317 | 0.86 | ALDH1A1 (0.57) | ALDH1A1HPGDLMNAHTTPOLB | |
| SCHEMBL8947118 | 0.86 | KDM4E (0.42) | ALDH1A1HPGDTP53SMN1; SMN2TRPV1 | |
| SCHEMBL8947122 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HPGDTP53HTTPOLB | |
| SCHEMBL8947184 | 0.83 | LMNA (0.48) | ALDH1A1HPGDLMNATP53HTT | |
| SCHEMBL8947140 | 0.83 | HSD11B1 (0.59) | ALDH1A1HPGDLMNAHTTSMN1; SMN2 | |
| SCHEMBL8947240 | 0.82 | ALDH1A1 (0.54) | ALDH1A1HPGDPOLBSMN1; SMN2TRPV1 | |
| SCHEMBL8947277 | 0.82 | TRPV1 (0.50) | ALDH1A1HPGDLMNAHTTSMN1; SMN2 | |
| SCHEMBL8947295 | 0.81 | TSHR (0.61) | ALDH1A1HPGDLMNATP53POLB | |
| SCHEMBL8947149 | 0.80 | ALDH1A1 (0.51) | ALDH1A1HPGDLMNAHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |
| EP-0379915-A1 | Substituted phenoxybenzonitrile derivatives, processes for their preparation and their use as herbicides and plant growth regulators | BAYER AG (DE) | 1990-08-01 | — | — | EP | disclosed |