Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469004 | 0.84 | TDP1 (0.42) | KMT2AKDM4EALDH1A1TDP1MGLL | |
| SCHEMBL8947258 | 0.84 | MAPT (0.55) | KMT2AKDM4EALDH1A1TDP1HSD11B1 | |
| SCHEMBL4407210 | 0.81 | TDP1 (0.65) | KMT2AALDH1A1TDP1TSHRALOX15 | |
| SCHEMBL9469693 | 0.79 | KDM4E (0.46) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL9689439 | 0.78 | KDM4E (0.45) | KMT2AKDM4EALDH1A1MGLLHDAC6 | |
| SCHEMBL9690579 | 0.78 | KDM4E (0.45) | KMT2AKDM4EALDH1A1MGLLPTGS2 | |
| SCHEMBL9688900 | 0.76 | KDM4E (0.41) | KDM4EALDH1A1ALOX15HDAC6PTGS2 | |
| SCHEMBL9690573 | 0.76 | KDM4E (0.43) | KMT2AKDM4EALDH1A1TSHRALOX15 | |
| SCHEMBL9689433 | 0.76 | ALDH1A1 (0.49) | KMT2AKDM4EALDH1A1HSD11B1TSHR | |
| SCHEMBL9688569 | 0.76 | KDM4E (0.43) | KMT2AKDM4EALDH1A1MGLLHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |