Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.43 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947138 | 0.84 | KMT2A (0.49) | ALDH1A1KDM4ETSHRTDP1HSD11B1 | |
| SCHEMBL4407210 | 0.75 | TDP1 (0.65) | MAPTL3MBTL1ALDH1A1TSHRTDP1 | |
| SCHEMBL10783107 | 0.75 | MAPK1 (0.41) | MAPTL3MBTL1ALDH1A1KDM4EGLA | |
| SCHEMBL9877332 | 0.74 | MAPT (0.54) | MAPTL3MBTL1ALDH1A1KDM4EGLA | |
| SCHEMBL8947294 | 0.73 | MAPK1 (0.61) | L3MBTL1ALDH1A1KDM4EHPGDCYP19A1 | |
| SCHEMBL8947161 | 0.72 | TP53 (0.46) | MAPTALDH1A1CYP19A1TP53TSHR | |
| SCHEMBL9799766 | 0.72 | MAPT (0.68) | MAPTL3MBTL1ALDH1A1KDM4EGLA | |
| SCHEMBL8947182 | 0.71 | HSD11B1 (0.65) | MAPTALDH1A1CYP19A1TSHRHSD11B1 | |
| SCHEMBL12781922 | 0.70 | MGLL (0.51) | MAPTL3MBTL1ALDH1A1HPGDCYP19A1 | |
| SCHEMBL8947145 | 0.69 | HSD11B1 (0.59) | ALDH1A1CYP19A1TSHRHSD11B1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |