Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | BID | P55957 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947081 | 0.82 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL8947241 | 0.80 | LMNA (0.46) | LMNAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8947255 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL8947264 | 0.79 | P2RX7 (0.49) | ALDH1A1KDM4E | |
| SCHEMBL926356 | 0.76 | LMNA (0.56) | LMNAALDH1A1RAB9A | |
| SCHEMBL8947269 | 0.74 | TRPV1 (0.43) | POLBLMNAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL8947317 | 0.71 | ALDH1A1 (0.57) | POLBLMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL8947311 | 0.71 | ALDH1A1 (0.57) | ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL8947250 | 0.71 | TRPV1 (0.48) | LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL8947336 | 0.70 | TRPV1 (0.56) | POLBLMNAALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |