Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GRK6 | P43250 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947241 | 0.90 | LMNA (0.46) | TRPV1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL8947334 | 0.87 | ALDH1A1 (0.56) | ALDH1A1HPGDKMT2AMEN1L3MBTL1 | |
| SCHEMBL8947122 | 0.85 | ALDH1A1 (0.47) | TRPV1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL8947081 | 0.84 | ALDH1A1 (0.47) | TRPV1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL8947255 | 0.83 | ALDH1A1 (0.46) | TRPV1ALDH1A1KMT2AMEN1L3MBTL1 | |
| SCHEMBL8947317 | 0.82 | ALDH1A1 (0.57) | TRPV1ALDH1A1HPGDKMT2AGAA | |
| SCHEMBL8947240 | 0.79 | ALDH1A1 (0.54) | TRPV1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL8947266 | 0.78 | ALDH1A1 (0.48) | TRPV1ALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL8947277 | 0.78 | TRPV1 (0.50) | TRPV1ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL8947149 | 0.76 | ALDH1A1 (0.51) | TRPV1ALDH1A1HPGDKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |