Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947269 | 0.90 | TRPV1 (0.43) | LMNAL3MBTL1TRPV1ALDH1A1MAPT | |
| SCHEMBL8947113 | 0.86 | ALDH1A1 (0.54) | LMNAL3MBTL1ALDH1A1MAPTHPGD | |
| SCHEMBL8947081 | 0.82 | ALDH1A1 (0.47) | TRPV1ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8947340 | 0.80 | BCL2 (0.45) | LMNAL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL8947255 | 0.80 | ALDH1A1 (0.46) | L3MBTL1TRPV1ALDH1A1MAPTMEN1 | |
| SCHEMBL7414782 | 0.80 | MAPT (0.43) | L3MBTL1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8947311 | 0.79 | ALDH1A1 (0.57) | L3MBTL1TRPV1ALDH1A1MAPTHPGD | |
| SCHEMBL8947122 | 0.78 | ALDH1A1 (0.47) | TRPV1ALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL8947334 | 0.77 | ALDH1A1 (0.56) | LMNAL3MBTL1ALDH1A1MAPTHPGD | |
| SCHEMBL8947266 | 0.76 | ALDH1A1 (0.48) | LMNATRPV1ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE35281-E | ANTIDIABETIC AGENTS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0388967-B1 | Aldose reductase inhibitor | WAKAMOTO PHARMA CO LTD (JP) | 1995-06-28 | — | — | EP | disclosed |
| US-5055481-A | Alleviate diabetic complications | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0388967-A1 | Aldose reductase inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1990-09-26 | — | — | EP | disclosed |