Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8947975 | 0.88 | SIGMAR1 (0.56) | — | |
| SCHEMBL8948053 | 0.87 | TSHR (0.52) | SMN1; SMN2NPC1LMNARAB9AGAA | |
| SCHEMBL8948121 | 0.87 | HTR2A (0.57) | LMNAMAPT | |
| SCHEMBL8948051 | 0.85 | HTR2A (0.55) | SMN1; SMN2LMNA | |
| SCHEMBL8948150 | 0.85 | HTR2A (0.55) | SMN1; SMN2LMNA | |
| SCHEMBL8948100 | 0.84 | SIGMAR1 (0.48) | — | |
| SCHEMBL8947939 | 0.82 | DRD2 (0.53) | — | |
| SCHEMBL11707845 | 0.81 | KDM4E (0.58) | — | |
| SCHEMBL8947963 | 0.80 | SIGMAR1 (0.50) | — | |
| SCHEMBL3028533 | 0.77 | DRD2 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |