Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948051 | 0.93 | HTR2A (0.55) | HTR2AHTR2CDRD2HSD11B1ALDH1A1 | |
| SCHEMBL8948034 | 0.87 | HTR2A (0.52) | HTR2AHTR2CDRD2ALDH1A1LMNA | |
| SCHEMBL8947958 | 0.85 | SMN1; SMN2 (0.55) | LMNASMN1; SMN2 | |
| SCHEMBL8948121 | 0.83 | HTR2A (0.57) | HTR2AHTR2CDRD2ALDH1A1LMNA | |
| SCHEMBL8947935 | 0.81 | HTR2A (0.59) | HTR2AHTR2CSIGMAR1HTR7HTR6 | |
| SCHEMBL8948192 | 0.81 | HTR1A (0.65) | HTR2AHTR2CHTR7 | |
| SCHEMBL8947963 | 0.81 | SIGMAR1 (0.50) | CNR2SIGMAR1 | |
| SCHEMBL8948061 | 0.80 | SIGMAR1 (0.52) | HTR2AHTR2CCNR2SIGMAR1HTR7 | |
| SCHEMBL8948000 | 0.80 | HTR2A (0.50) | HTR2AHTR2CDRD2SIGMAR1HTR7 | |
| SCHEMBL8948058 | 0.80 | CNR2 (0.49) | HTR2AHTR2CDRD2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |