Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.57 |
| ▸ | HTR2C | P28335 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948079 | 0.88 | HTR2A (0.62) | HTR1AHTR2CKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8947962 | 0.88 | KCNH2 (0.57) | HTR1AHTR2CKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8948027 | 0.88 | HTR1A (0.57) | HTR1AHTR2CKDM4ECYP1A2CYP3A4 | |
| SCHEMBL9161222 | 0.83 | LMNA (0.47) | LMNATSHRSMN1; SMN2KDM4ECYP1A2 | |
| SCHEMBL8948202 | 0.81 | HTR2C (0.67) | HTR1AHTR2CTSHRKDM4ECYP1A2 | |
| SCHEMBL8947963 | 0.79 | SIGMAR1 (0.50) | — | |
| SCHEMBL8948067 | 0.77 | HTR1A (0.56) | HTR1ALMNATSHRSMN1; SMN2KDM4E | |
| SCHEMBL8958326 | 0.74 | SIGMAR1 (0.67) | HTR1AHTR2CTSHRCYP1A2CYP3A4 | |
| SCHEMBL7247553 | 0.74 | POLB (0.61) | LMNATSHRSMN1; SMN2KCNH2SLC18A3 | |
| SCHEMBL9227281 | 0.74 | KCNH2 (0.64) | LMNATSHRSMN1; SMN2KCNH2SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |