Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.61 |
| ▸ | HTR2C | P28335 | 8/20 | 0.61 |
| ▸ | LSS | P48449 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467277 | 0.96 | HTR1A (0.61) | HTR1AHTR2CLSSDRD2HTR2A | |
| SCHEMBL8948219 | 0.91 | HTR1A (0.70) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL7756727 | 0.85 | HTR1A (0.64) | HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL8947912 | 0.84 | HTR1A (0.85) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL7756745 | 0.84 | HTR1A (0.63) | HTR1AHTR2CDRD2HTR2A | |
| SCHEMBL7763020 | 0.82 | HTR1A (0.62) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL8785423 | 0.82 | HTR1A (0.69) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL8948002 | 0.80 | HTR1A (0.87) | HTR1AHTR2CDRD2HTR2ASIGMAR1 | |
| SCHEMBL8958326 | 0.80 | SIGMAR1 (0.67) | HTR1AHTR2CSIGMAR1 | |
| SCHEMBL8786197 | 0.80 | HTR1A (0.81) | HTR1AHTR2CDRD2HTR2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |