SCHEMBL8948052

SCHEMBL8948052

O=C(O)c1ccccc1-c1c2ccc(=O)c([N+](=O)[O-])c-2oc2c([N+](=O)[O-])c(O)ccc12

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GNG2 P59768 3/20 0.65
GNB1 P62873 3/20 0.65
PTPN7 P35236 1/20 0.55
USP2 O75604 3/20 0.43
KDM4A O75164 2/20 0.43
PLCG1 P19174 2/20 0.43
TNNI3 P19429 2/20 0.43
TNNT2 P45379 2/20 0.43
MMP14 P50281 2/20 0.43
CASP6 P55212 2/20 0.43
TNNC1 P63316 2/20 0.43
KDM4C Q9H3R0 2/20 0.43
NSD2 O96028 1/20 0.43
ALPL P05186 1/20 0.43
NFKB1 P19838 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
MCL1 Q07820 1/20 0.41
FTO Q9C0B1 2/20 0.41
SOS1 Q07889 1/20 0.41
MEN1 O00255 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14960107 0.88 GNG2 (0.50) GNG2GNB1PTPN7USP2KDM4A
SCHEMBL2777300 0.79 GNG2 (1.00) GNG2GNB1PTPN7USP2KDM4A
SCHEMBL29588006 0.76 GNG2 (0.70) GNG2GNB1PTPN7USP2KDM4A
SCHEMBL15424239 0.76 GNG2 (0.70) GNG2GNB1PTPN7USP2KDM4A
SCHEMBL14001247 0.76 GNG2 (0.70) GNG2GNB1PTPN7USP2KDM4A
SCHEMBL6125804 0.76 GNG2 (0.70) GNG2GNB1PTPN7USP2KDM4A
SCHEMBL1645805 0.76 GNG2 (0.70) GNG2GNB1PTPN7USP2KDM4A
SCHEMBL21611728 0.75 GNG2 (0.69) GNG2GNB1PTPN7USP2KDM4A
SCHEMBL14030799 0.74 GNG2 (0.67) GNG2GNB1PTPN7USP2KDM4A
SCHEMBL14627030 0.73 GNG2 (0.61) GNG2GNB1PTPN7USP2KDM4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9504637-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2016-11-29 US disclosed
US-9504637-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2016-11-29 US disclosed
US-20160106648-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. (US) 2016-04-21 US disclosed
US-20160106648-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. (US) 2016-04-21 US disclosed
US-9248086-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2016-02-02 US disclosed
US-9248086-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2016-02-02 US disclosed
US-20150174026-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. 2015-06-25 US disclosed
US-20150174026-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. 2015-06-25 US disclosed
US-8932370-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2015-01-13 US disclosed
US-8932370-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2015-01-13 US disclosed
US-20140013520-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. 2014-01-16 US disclosed
US-20140013520-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. 2014-01-16 US disclosed
US-8444715-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2013-05-21 US disclosed
US-20120272990-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. (US) 2012-11-01 US disclosed
US-20120272990-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. (US) 2012-11-01 US disclosed
US-8187340-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2012-05-29 US disclosed
US-8187340-B2 Coloring agents and methods of use thereof LIVING PROOF, INC. (US) 2012-05-29 US disclosed
WO-2011084803-A2 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. (US) 2011-07-14 WO disclosed
US-20110154583-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. (US) 2011-06-30 US disclosed
US-20110154583-A1 COLORING AGENTS AND METHODS OF USE THEREOF LIVING PROOF, INC. (US) 2011-06-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120272990-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 GNG2 2263/4885GNB1 2876/4885PTPN7 1480/4885
US-20110154583-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 GNG2 2263/4885GNB1 2876/4885PTPN7 1480/4885
US-20160106648-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 GNG2 2263/4885GNB1 2876/4885PTPN7 1480/4885
US-20140013520-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 GNG2 2263/4885GNB1 2876/4885PTPN7 1480/4885
US-20150174026-A1 COLORING AGENTS AND METHODS OF USE THEREOF MPO, HLA-C, ADH7 GNG2 2263/4885GNB1 2876/4885PTPN7 1480/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.