Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948001 | 0.85 | HTR2A (0.43) | CNR2SIGMAR1HTR2AHTR2CHTR7 | |
| SCHEMBL8948061 | 0.83 | SIGMAR1 (0.52) | CNR2SIGMAR1HTR2AHTR2CHTR7 | |
| SCHEMBL8948034 | 0.81 | HTR2A (0.52) | CNR2SIGMAR1HTR2AHTR2CHTR7 | |
| SCHEMBL8948150 | 0.80 | HTR2A (0.55) | CNR2SIGMAR1HTR2AHTR2CHTR7 | |
| SCHEMBL8948121 | 0.78 | HTR2A (0.57) | SIGMAR1HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL8948003 | 0.77 | HTR2A (0.44) | CNR2HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL8947935 | 0.76 | HTR2A (0.59) | SIGMAR1HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL8948051 | 0.74 | HTR2A (0.55) | HTR2AHTR2CHTR7HTR6ALDH1A1 | |
| SCHEMBL8948078 | 0.74 | HTR2A (0.55) | CNR2SIGMAR1HTR2AHTR2CHTR7 | |
| SCHEMBL8947974 | 0.74 | SIGMAR1 (0.64) | SIGMAR1HTR2AHTR2CHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534517-A | (Aryl(alkyl)carbonyl)-heterocyclic compounds and their use in the treatment of anxiety and depression | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| US-5387586-A | Analgesics, nervous system disorders | ADIR ET COMPAGNIE (FR) | 1995-02-07 | — | — | US | disclosed |
| EP-0613898-A1 | Aryl or arylalkyl-carbonyl heterocyclic derivatives, processes for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-09-07 | — | — | EP | disclosed |