Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RGS12 | O14924 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8948586 | 0.76 | TYMS (0.40) | PARP1ADORA2APTPRCPOLBALDH1A1 | |
| SCHEMBL11381582 | 0.75 | ALDH1A1 (0.44) | POLBALDH1A1L3MBTL1MEN1CYP1A2 | |
| SCHEMBL11159842 | 0.75 | RAB9A (0.40) | POLBALDH1A1L3MBTL1MEN1USP2 | |
| SCHEMBL8948740 | 0.73 | CA1 (0.49) | PTPRCPOLBALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL10928680 | 0.73 | KDM4E (0.37) | PARP1POLBALDH1A1L3MBTL1MEN1 | |
| Hydrochloric Acid SCHEMBL11160479 | 0.72 | — | — | |
| SCHEMBL11089110 | 0.72 | PARP1 (0.33) | PARP1ALDH1A1MEN1CYP1A2CYP3A4 | |
| SCHEMBL11158055 | 0.72 | MAPT (0.45) | POLBALDH1A1L3MBTL1MEN1USP2 | |
| SCHEMBL11155587 | 0.71 | DDB1 (0.37) | ALDH1A1L3MBTL1MEN1CYP1A2CYP3A4 | |
| SCHEMBL11154239 | 0.69 | ALDH1A1 (0.46) | ALDH1A1L3MBTL1MAPTCASP1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5521147-A | HERBICIDES | FMC CORPORATION (US) | 1996-05-28 | — | — | US | disclosed |
| WO-1995005079-A1 | 3-(BENZOFURAN-7-YL)-6-HALOALKYLURACILS | FMC CORPORATION (US) | 1995-02-23 | — | — | WO | disclosed |
| EP-0018830-B1 | SPIROBENZOFURANONES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Chemical Industries, Ltd. (JP) | 1983-06-08 | — | — | EP | disclosed |
| EP-0003084-B1 | SPIROBENZOFURANONE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | Takeda Chemical Industries, Ltd. (JP) | 1982-02-24 | — | — | EP | disclosed |
| US-4284644-A | Spirobenzofuranone compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| EP-0018830-A2 | Spirobenzofuranones, their production and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1980-11-12 | — | — | EP | disclosed |
| EP-0003084-A1 | Spirobenzofuranone compounds, processes for their preparation and their use as medicines | Takeda Chemical Industries, Ltd. (JP) | 1979-07-25 | — | — | EP | disclosed |