SCHEMBL8948747

SCHEMBL8948747

CC1(C)Cc2c(Cl)cc(F)c(N)c2O1

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.33
PTGES O14684 2/20 0.32
ALDH1A1 P00352 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
FFAR4 Q5NUL3 3/20 0.31
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA9 Q16790 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8948707 0.84 GRM2 (0.34)
SCHEMBL8389994 0.74 HTR2A (0.33) HTR2AALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL10044410 0.73 ALDH1A1 (0.39) HTR2AALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL8948519 0.73 ALDH1A1 (0.37) HTR2AALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL9218811 0.73 CA1 (0.33) CA1CA2CA9
SCHEMBL8117537 0.69 ALDH1A1 (0.38) HTR2AALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL8948549 0.69 ACHE (0.38)
SCHEMBL8948775 0.68 ALDH1A1 (0.39) HTR2AALDH1A1FFAR4
Hydrochloric Acid SCHEMBL8117330 0.68 ALDH1A1 (0.37) HTR2AALDH1A1CYP1A2CYP3A4CYP2D6
SCHEMBL8948565 0.68 NLRP3 (0.38) PTGESALDH1A1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5521147-A HERBICIDES FMC CORPORATION (US) 1996-05-28 US disclosed
WO-1995005079-A1 3-(BENZOFURAN-7-YL)-6-HALOALKYLURACILS FMC CORPORATION (US) 1995-02-23 WO disclosed