Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8949043 | 1.00 | HSD11B1 (0.38) | HSD11B1ALDH1A1SMN1; SMN2DGAT1POLB | |
| SCHEMBL8949077 | 0.91 | HTR2B (0.39) | ALDH1A1SMN1; SMN2POLBCYP1A2CYP2C9 | |
| SCHEMBL9571663 | 0.91 | HTR2B (0.39) | ALDH1A1SMN1; SMN2POLBCYP1A2CYP2C9 | |
| SCHEMBL8949176 | 0.76 | POLB (0.36) | POLBSYKITGB3PRSS1PRSS2 | |
| SCHEMBL8949178 | 0.76 | POLB (0.36) | POLBSYKITGB3PRSS1PRSS2 | |
| SCHEMBL8949363 | 0.75 | TMPRSS15 (0.43) | POLBSYKPRSS1PRSS2PRSS3 | |
| SCHEMBL8949356 | 0.75 | TMPRSS15 (0.43) | POLBSYKPRSS1PRSS2PRSS3 | |
| SCHEMBL8948981 | 0.73 | GPR119 (0.38) | POLBSYKITGB3ITGA2B | |
| SCHEMBL8948974 | 0.73 | GPR119 (0.38) | POLBSYKITGB3ITGA2B | |
| SCHEMBL8949416 | 0.72 | ITGB3 (0.39) | DGAT1POLBSYKITGB3PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563268-A | FOR PREVENTING CELL AGGLOMERATION, TREATING THROMBOSIS, ARTERIOSCLEROSIS, BRAIN, LUNG OR CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-10-08 | — | — | US | disclosed |
| US-5418233-A | FOR INHIBITING CELL AGGREGATION | KARL THOMAE GMBH (DE) | 1995-05-23 | — | — | US | disclosed |
| EP-0537696-A1 | Heterobiaryl derivatives, medicines containing those compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-04-21 | — | — | EP | disclosed |