Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GPR139 | Q6DWJ6 | 7/20 | 0.52 |
| ▸ | PRCP | P42785 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900323 | 0.90 | ACACA (0.56) | SMN1; SMN2ALDH1A1LMNAHTTGPR139 | |
| SCHEMBL7897298 | 0.86 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1LMNAHTTGPR139 | |
| SCHEMBL6400133 | 0.85 | MAPT (0.69) | ALDH1A1GPR139GAAHPGDMAPT | |
| SCHEMBL31373866 | 0.85 | MAPT (0.69) | ALDH1A1GPR139GAAHPGDMAPT | |
| SCHEMBL6398811 | 0.85 | MAPT (0.69) | ALDH1A1GPR139GAAHPGDMAPT | |
| SCHEMBL7677571 | 0.84 | MEN1 (0.59) | SMN1; SMN2ALDH1A1LMNAGPR139PRCP | |
| SCHEMBL7681216 | 0.84 | MEN1 (0.59) | SMN1; SMN2ALDH1A1LMNAGPR139PRCP | |
| SCHEMBL8445815 | 0.83 | GPR139 (0.55) | SMN1; SMN2ALDH1A1LMNAHTTGPR139 | |
| SCHEMBL23122289 | 0.81 | GPR139 (0.54) | SMN1; SMN2ALDH1A1LMNAHTTGPR139 | |
| SCHEMBL7932227 | 0.81 | GPR139 (0.54) | SMN1; SMN2ALDH1A1LMNAHTTGPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1037511-C | Therapeutic agents | BOOTS CO PLC (GB) | 1998-02-25 | — | — | CN | disclosed |
| US-5547972-A | 1-(ARLALKYLAMINOALKYL) IMIDAZOLE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1996-08-20 | — | — | US | disclosed |
| CN-1096781-A | The therapeutical agent that contains 1-(aralkyl-aminoalkyl) imidazolium compounds | BOOTS CO PLC (GB) | 1994-12-28 | — | — | CN | disclosed |
| EP-0618907-A1 | 1-(ARYLALKYL-AMINOALKYL)IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARATION AND USE AS THERAPEUTICAL AGENTS | Knoll AG (DE) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993013075-A1 | 1-(ARYLALKYL-AMINOALKYL)IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARATION AND USE AS THERAPEUTICAL AGENTS | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |