Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446189 | 0.87 | ALDH1A1 (0.50) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL29348752 | 0.85 | HDAC1 (0.45) | HDAC1HDAC3HDAC4HDAC2HDAC10 | |
| SCHEMBL8949485 | 0.85 | NPC1 (0.43) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL8446802 | 0.84 | ALDH1A1 (0.55) | HDAC1HDAC3HDAC2POLBALDH1A1 | |
| SCHEMBL8949311 | 0.84 | NPC1 (0.44) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL27327646 | 0.83 | HDAC1 (0.40) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL8447174 | 0.80 | L3MBTL1 (0.46) | POLBALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8949430 | 0.80 | POLB (0.44) | POLBALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8743677 | 0.77 | POLB (0.46) | POLBALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8443619 | 0.77 | L3MBTL1 (0.49) | POLBALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5547972-A | 1-(ARLALKYLAMINOALKYL) IMIDAZOLE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1996-08-20 | — | — | US | disclosed |
| EP-0618907-A1 | 1-(ARYLALKYL-AMINOALKYL)IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARATION AND USE AS THERAPEUTICAL AGENTS | Knoll AG (DE) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993013075-A1 | 1-(ARYLALKYL-AMINOALKYL)IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARATION AND USE AS THERAPEUTICAL AGENTS | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |