SCHEMBL8949436

SCHEMBL8949436

NCC(=O)OS(=O)(=O)c1ccc(C(F)(F)F)cc1.[NaH]

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 2/20 0.44
CA1 P00915 3/20 0.43
CA2 P00918 3/20 0.43
CA9 Q16790 2/20 0.43
CA12 O43570 2/20 0.43
MAPT P10636 1/20 0.43
MMP1 P03956 2/20 0.42
KMT2A Q03164 1/20 0.41
ENPP3 O14638 5/20 0.40
ENPP1 P22413 4/20 0.40
ENPP2 Q13822 4/20 0.40
SLC1A3 P43003 1/20 0.40
SLC1A2 P43004 1/20 0.40
SLC1A1 P43005 1/20 0.40
HSD11B1 P28845 1/20 0.39
MAOB P27338 1/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CA7 P43166 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5685915 0.77 ALDH1A1 (0.56) CA1CA2CA9CA12MMP1
SCHEMBL27716097 0.76 MAPT (0.41) CA1CA2CA9CA12MAPT
SCHEMBL8843455 0.74 F2 (0.50) CA1CA2MMP1ALDH1A1
SCHEMBL8123743 0.72 KIF11 (0.53) KIF11CA1CA2CA9CA12
SCHEMBL29068282 0.71 KIF11 (0.59) KIF11CA1CA2CA9MAPT
SCHEMBL4225010 0.71 KIF11 (0.53) KIF11CA1CA2CA9CA12
SCHEMBL6114563 0.71 PTGS2 (0.50) KIF11CA1CA2CA9MMP1
SCHEMBL2006613 0.71 KIF11 (0.50) KIF11CA1CA2CA9CA12
SCHEMBL21595326 0.69 PTGS2 (0.49) KIF11CA1CA2CA9MMP1
SCHEMBL6921092 0.69 IDO1 (0.55) MMP1KMT2AMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5573708-A ACID-SUBSTITUTED PERFLUOROALKYLBENZENES UNION CHEMICAL CO., LTD. (JP) 1996-11-12 US claimed
EP-0569884-B1 Rust inhibitor UNION CHEMICAL CO LTD (JP) 1996-09-18 EP claimed
US-5487846-A FLUORINE-SUBSTITUTED BENZENE DERIVATIVES UNION CHEMICAL CO., LTD. (JP) 1996-01-30 US claimed
EP-0569884-A1 Rust inhibitor UNION CHEMICAL CO., LTD. (JP) 1993-11-18 EP claimed
EP-0569884-B1 Rust inhibitor UNION CHEMICAL CO LTD (JP) 1996-09-18 EP disclosed
US-5487846-A FLUORINE-SUBSTITUTED BENZENE DERIVATIVES UNION CHEMICAL CO., LTD. (JP) 1996-01-30 US disclosed
EP-0569884-A1 Rust inhibitor UNION CHEMICAL CO., LTD. (JP) 1993-11-18 EP disclosed