Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 4/20 | 0.52 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799786 | 0.93 | GABBR2 (0.50) | GABBR2GABBR1CYP1A2TSHRTHPO | |
| SCHEMBL8949817 | 0.91 | GABBR2 (0.48) | GABBR2GABBR1CYP1A2TSHRTHPO | |
| SCHEMBL8949921 | 0.91 | GABBR2 (0.48) | GABBR2GABBR1CYP1A2TSHRTHPO | |
| Phosphoric Acid SCHEMBL27481355 | 0.84 | BLM (0.52) | GABBR2GABBR1CYP1A2TSHRTHPO | |
| Phosphoric Acid SCHEMBL6535607 | 0.84 | BLM (0.52) | GABBR2GABBR1CYP1A2TSHRTHPO | |
| Butylamine SCHEMBL8949981 | 0.80 | GABBR2 (0.58) | GABBR2GABBR1CYP1A2TSHRTHPO | |
| SCHEMBL8950061 | 0.78 | GABBR2 (0.56) | GABBR2GABBR1CYP1A2TSHRTHPO | |
| SCHEMBL8949882 | 0.76 | DNM1 (0.59) | GABBR2GABBR1TSHRGABRR1FDPS | |
| Propylamine SCHEMBL8950040 | 0.76 | GABBR2 (0.46) | GABBR2GABBR1CYP1A2TSHRTHPO | |
| Phosphoric Acid SCHEMBL27508186 | 0.76 | LMNA (0.50) | GABBR2GABBR1CYP1A2TSHRTHPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574024-A | Methylene phosphonoalkylphosphinates, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism | EBETINO FRANK H (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0298553-B1 | METHYLENE PHOSPHONOALKYLPHOSPHINATES, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR TREATING ABNORMAL CALCIUM AND PHOSPHATE METABOLISM | Norwich Eaton Pharmaceuticals, Inc. (US) | 1992-01-15 | — | — | EP | disclosed |