SCHEMBL8950295

SCHEMBL8950295

O=C1C(c2ccccc2Cl)C(=O)N2CCCCN12

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.45
TP53 P04637 1/20 0.43
RECQL P46063 1/20 0.43
ALDH1A1 P00352 3/20 0.42
KDM4E B2RXH2 2/20 0.41
MAPT P10636 1/20 0.41
TSHR P16473 2/20 0.40
DPP4 P27487 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8950185 0.80 SMN1; SMN2 (0.47) ALDH1A1KDM4EMAPTTSHRSMN1; SMN2
SCHEMBL8950429 0.79 ALDH1A1 (0.46) ALDH1A1KDM4EMAPTTSHRDPP4
SCHEMBL8950302 0.79 GAA (0.40) ALDH1A1KDM4EMAPTTSHR
SCHEMBL7891052 0.76 KDM4E (0.47) CHRNA7TP53RECQLALDH1A1KDM4E
SCHEMBL2363015 0.74 ALDH1A1 (0.39) TP53ALDH1A1MAPTTSHR
SCHEMBL909045 0.73 ROCK2 (0.43) CHRNA7TP53RECQLALDH1A1KDM4E
SCHEMBL8950233 0.73 MAPT (0.41) TP53ALDH1A1MAPTTSHRSMN1; SMN2
SCHEMBL8950369 0.73 LMNA (0.43) TP53RECQLALDH1A1MAPTTSHR
SCHEMBL18149004 0.72 ROCK2 (0.47) CHRNA7TP53RECQLALDH1A1KDM4E
SCHEMBL10736168 0.72 TP53 (0.47) TP53RECQLALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0577629-B1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS CIBA GEIGY AG (CH) 1996-06-26 EP claimed
EP-0577629-A1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS. CIBA GEIGY AG (CH) 1994-01-12 EP claimed
WO-1992016510-A1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS CIBA-GEIGY AG (CH) 1992-10-01 WO claimed
EP-0577629-B1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS CIBA GEIGY AG (CH) 1996-06-26 EP disclosed
US-5506193-A Herbicidally, acaricidally and insecticidally active pyrazolidine compounds CIBA-GEIGY CORPORATION (US) 1996-04-09 US disclosed
US-5494890-A FOR CONTROLLING WEEDS, INSECTS, MITES CIBA-GEIGY CORPORATION (US) 1996-02-27 US disclosed
EP-0577629-A1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS. CIBA GEIGY AG (CH) 1994-01-12 EP disclosed
WO-1992016510-A1 NOVEL HERBICIDALLY, ACARICIDALLY AND INSECTICIDALLY ACTIVE COMPOUNDS CIBA-GEIGY AG (CH) 1992-10-01 WO disclosed