Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | PKM | P14618 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8950101 | 0.86 | PKM (0.46) | LMNAPKMKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8950105 | 0.71 | ALDH1A1 (0.39) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL1936832 | 0.68 | MEN1 (0.57) | LMNAPKMKMT2AMEN1HPGD | |
| SCHEMBL1936151 | 0.68 | PPARG (0.60) | LMNAPKMKMT2AMEN1HPGD | |
| SCHEMBL10373935 | 0.68 | ALDH1A1 (0.45) | ALDH1A1 | |
| SCHEMBL4662755 | 0.67 | PGR (0.72) | LMNAPKMKMT2AMEN1HPGD | |
| SCHEMBL8711296 | 0.67 | CYP19A1 (0.88) | LMNAPKMKMT2AMEN1HPGD | |
| SCHEMBL9079085 | 0.67 | ALDH1A1 (0.35) | LMNASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL3057133 | 0.66 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL3017019 | 0.66 | ALDH1A1 (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022099-A1 | OPHTHALMIC COMPOSITIONS FOR TREATING GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5538966-A | ENZYME INHIBITORS FOR TREATMENT OF GLAUCOMA | ALCON LABORATORIES, INC. (US) | 1996-07-23 | — | — | US | disclosed |
| WO-1995019981-A1 | THIENOTHIAZINE SULFONAMIDE DERIVATIVES PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS CARBONIC ANHYDRASE INHIBITORS | ALCON LABORATORIES, INC. (US) | 1995-07-27 | — | — | WO | disclosed |